Background:
@EN Retinoids are strong inhibitors of epithelial cancer promotion and progression in experimental carcinogenesis. Recently, therapeutic trial of retinoids have demonstrated activities in cervical cancer and precancerous lesion of cervix. Our
purpose
was to determine whether the administraion of 13-cis-retinoic acid is more effectual in the neoadjuvant chemotherapy of cervical carcinoma.
@ES Methods:
@EN From January 1994 through January 1995, 40 patients with invasive cervical cancer were enrolled in this prospective study and divided by two gourps. Group 1 had neoadjunant chemotherapy alone and group 2 had neoadjuvangt chemotherapy plus
13-cis-retinoic acid(RA) at a dosage of 1 mg/kg/day for 1 month. Patients between group 1 and group 2 were similar with respect to age, parity, clinical stage, and histological subtype. Therapeutic responses were compared using Fisher's exact
test,
Mann-Whitney test, and Wilcoxon signed rank test.
@ES Results:
@EN RA increased the complete response rate of neoadjuvant chemotherapy from 0% in the group 1 to 5% in group 2. But difference of overall response rate between two groups was not evident. The drug toxicities between group 1 and group 2 included
anemia
in 30.0% and 23.7%, leukopenia in 6.7% and 15.2 %and hepatotoxicity in 6.7% and 6.8%respectively. More skin side effects were seen in the patients of group 2, but these effects were mild and reversible.
@ES Conclusion:
@EN It would be suggested that RA plus chemotherapy may be superior chemotherapy alone in increasing the complete response rate of neoadjuvant chemotherapy forpatients with cervical cancer. The impact of such a treatment on survival needs to be
further
explored.
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